IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

•The publication is a report of an international working group.•Approaches for quantitative assessment of genotoxic risk are recommended.•Extrapolation from derived points of departure to estimate human risk is discussed.•Selection of endpoints and tissues in vivo and the use of in vitro data are discussed.•Considerations include uncertainty factors, metabolism, exposure, DNA reactivity.