Metal-organic framework biosensor with high stability and selectivity in a bio-mimic environment.

A water-stable copper metal-organic framework (MOF), {[Cu-2(HL)(2)(mu(2)-OH)(2)(H2O)(5)]center dot H2O}(n) (1, H2L = 2,5-dicarboxylic acid-3,4-ethylene dioxythiophene), was applied for the electrochemical detection of ascorbic acid (AA) without further post-modification. A glass carbon electrode covered with 1 was used as a biosensor for the simultaneous detection of AA and L-tryptophan (L-Trp) from both a single-component solution and a bio-mimic environment.