Corticosteroid responses following hypoxic preconditioning provide neuroprotection against subsequent hypoxic-ischemic brain injury in the newborn rats.
International Journal of Developmental Neuroscience（2015）
Abstract
•Hypoxic PC in newborn rats.•Causes corticosteroid surge.•Augments HI induced corticosteroid surge.•Preserves glucocorticoid feedback regulation after HI.•Glucocorticoid receptor blocker, RU486 before hypoxic PC.•Inhibits PC induced neuroprotection against HI.
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Key words
Akt,CS,GR,HI,PC
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