Only extra-high dose of ketamine affects l-glutamate-induced intracellular Ca2+ elevation and neurotoxicity

Satoshi Shibuta,Tomotaka Morita,Jun Kosaka,Takahiko Kamibayashi,Yuji Fujino

Neuroscience Research（2015）

Cited 9|Views3

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Abstract

•Glu-induced Ca elevation/toxicity in neurons once exposed to anesthetics examined.•Ca-imaging and morphological experiments were used.•Once high dose ketamine exposure enhanced Glu-induced Ca elevation 2 weeks later.•Once exposed ketamine slightly enhanced vulnerability against Glu-induced toxicity.•Once exposed TPS not potentiated Glu-induced Ca elevation/neurotoxicity.

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Key words

5-FU,AMPA,ANOVA,AR,[Ca2+]i,CCD,DIV,DMEM,E17,FCS,Fmax,GABA,GFAP,HR,HS,HSD,NBS,NF-κB,NMDA,PBS,PD,SEM,SR,TPS

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