Efficacy and Safety of Intravitreal Dexamethasone Implant in Patients with Diabetic Macular Edema.

Purpose: To evaluate the efficacy and safety of intravitreal implant of dexamethasone (Ozurdex (R)) in diabetic macular edema (DME). Methods:This was a retrospective multicenter noncomparative study. Seventy-eight patients with DME followed for at least 6 months were included (P1.5 Network). Best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP) and cataract progression were studied at baseline and then at 1, 2, 4 and 6 months. Results:The mean CRT decrease from baseline was 145.2 mu m at 6 months. The mean BCVA improvement from baseline was 6.7 at 6 months. An increase in IOP was observed for 11.7% of patients, and all patients were managed by topical treatment. No glaucoma or cataract surgery was necessary, and no endophthalmitis was reported. Conclusions: One injection of Ozurdex has an anatomical and functional effectiveness for the treatment of DME. Side effects were rare and manageable in our practice. (C) 2015 S. Karger AG, Basel