Gata3 cooperates with Gcm2 and MafB to activate parathyroid hormone gene expression by interacting with SP1.

Song-Iee Han,Yukino Tsunekage,Kohsuke Kataoka

Molecular and Cellular Endocrinology（2015）

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摘要

•Gata3 activated parathyroid hormone (PTH) gene promoter.•Gata3 interacted with Gcm2 and MafB and synergistically stimulated the PTH promoter.•An SP1-binding element within the PTH-promoter was critical for activation by Gata3.•Ubiquitous transcription factor SP1 interacted with Gata3, MafB, and Gcm2.•HDR syndrome-associated Gata3 mutants were defective in activating the PTH promoter.

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关键词

Parathyroid hormone,Transcriptional regulation,Gata3,MafB,Gcm2,Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome

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