Evaluating drug delivery with salt formation: Drug disproportionation studied in situ by ATR-FTIR imaging and Raman mapping.

Andrew V Ewing,Patrick S Wray,Graham S Clarke,Sergei G Kazarian

Journal of Pharmaceutical and Biomedical Analysis（2015）

引用 26|浏览3

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摘要

•ATR-FTIR spectroscopic imaging and Raman mapping used to assess disproportionation.•Dynamic dissolution of tablets studied using these approaches for the first time.•Structural changes were characterised that prevented drug release.

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关键词

FT-IR spectroscopy,Raman spectroscopy,Chemical imaging,Salt formation,Dissolution

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