Evaluation of the repeated-dose liver, bone marrow and peripheral blood micronucleus and comet assays using kojic acid.

Ogiwara Yosuke,Sugiura Mihoko,Watanabe Kumiko,Tawara Junko,Endo Emi,Maruyama Hiromi,Tsuji Satoshi,Matsue Kenta,Yamada Hisaharu,Wako Yumi,Kawasako Kazufumi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•Repeated dosing of kojic acid is non-genotoxic in the liver, and bone marrow.•Multiple genotoxic study could be integrated into general toxicological studies.•The liver micronucleus assay is a simple method and could detect hepatocarcinogens.

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关键词

Genotoxicity,Micronucleus assay,Comet assay,Kojic acid,Liver

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