Repeated dose liver and gastrointestinal tract micronucleus assays using N-methyl-N'-nitro-N-nitrosoguanidine in young adult rats.

Takayanagi Tomomi,Wako Yumi,Kawasako Kazufumi,Hori Hisako,Fujii Wataru,Ohyama Wakako

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•We conducted 14- and 28-day repeated dose rat micronucleus (MN) assays with MNNG.•The MNed cell frequencies were examined in the liver, bone marrow, stomach and colon.•Clearly positive results were only obtained in the glandular stomach in both studies.•The tissue specificity of MNNG was detected using the MN assay with multiple tissues.

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关键词

Micronucleus assay,Repeated dose study,Liver,Glandular stomach,Colon,N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)

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