Repeated-dose liver and gastrointestinal tract micronucleus assays for quinoline in rats.

Uno Fuyumi,Tanaka Jin,Ueda Maya,Nagai Miho,Fukumuro Masahito,Natsume Masakatsu,Oba Michiyo,Akahori Ayaka,Masumori Shoji,Takami Shigeaki,Wako Yumi,Kawasako Kazufumi,Kougo Yuriko,Ohyama Wakako,Narumi Kazunori,Fujiishi Yohei,Okada Emiko,Hayashi Makoto

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•We conducted the RDLMN assays using quinoline in young adult rats.•The MNHEPs in the quinoline-treated groups were significantly increased.•The numbers of micronucleated stomach, colon and bone marrow cells did not increase.•The RDLMN assay is useful for detecting liver carcinogens.•The RDLMN assay is capable of being incorporated into general toxicity studies.

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关键词

Liver micronucleus assay,Gastrointestinal tract,Bone marrow,Quinoline,Repeated-dose toxicity study

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