Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates neurohormonal excitation in high salt-induced hypertension.

•Salt-induced hypertensive rats exhibit neurohormonal excitation in the PVN.•PVN PEG-CAT attenuates neurohormonal excitation and expression of RAS in hypertension.•PVN PEG-CAT attenuates imbalances of neurotransmitters and cytokines in hypertension.•PVN ATZ augments hypertension-induced neurohormonal excitation and expression of RAS.•PVN ATZ augments hypertension-induced imbalances of neurotransmitters and cytokines.