Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.

Kutty R Krishnan,Samuel William,Abay Rebecca,Cherukuri Aswini,Nagineni Chandrasekharam N,Duncan Todd,Jaworski Cynthia,Vijayasarathy Camasamudram,Redmond T Michael

Cytokine（2015）

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摘要

•IFN-γ, IL-1β and TNF-α highly increased the production of CXCL11 by RPE cells.•Resveratrol suppressed the proinflammatory cytokines-induced CXCL11 production.•Resveratrol also blocked nuclear factor-κB activation by proinflammatory cytokines.•Resveratrol may attenuate RPE inflammatory response implicated in AMD.

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关键词

RPE,AMD,NF-κB

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