Viral immune evasion: Lessons in MHC class I antigen presentation.

van de Weijer Michael L,Luteijn Rutger D,Wiertz Emmanuel J H J

Seminars in Immunology（2015）

引用 80|浏览15

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摘要

•MHC class I presents peptides from endogenous proteins for detection by CD8+ T cells.•The MHC I antigen presentation pathway is targeted by an array of viral inhibitors.•These viral inhibitors have offered great insights into MHC I antigen presentation.•These viral inhibitors are great research tools and hold therapeutic potential.

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关键词

ABC,β2m,DC,BHV,EBNA-1,EBV,EHV,ERAD,ExoA,HC,HCMV,HSV-1,LANA-1,KSHV,MHC I/II,MARCH,MHV,MIR,NBD,OVA,PLC,SP,SPP,SRP,TAP,TEIPP,TM

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