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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

Alfred B Tiono,Halidou Tinto,Maroufou J Alao,Martin Meremikwu,Antoinette Tshefu,Bernhards Ogutu,Alphonse Ouedraogo,Moussa Lingani,Marc Cousin,Gilbert Lefèvre,Jay Prakash Jain,Stephan Duparc,Kamal Hamed

Malaria Journal（2015）

Cited 9|Views16
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Abstract
Artemether-lumefantrine (AL) dispersible formulation was developed for the treatment of uncomplicated Plasmodium falciparum malaria in infants and children weighing 5 to <35 kg. However, there are no clinical studies with artemisinin-based combination therapy in infants <5 kg.
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Key words
Artemether-lumefantrine,Dispersible,Efficacy,Infants,Pharmacokinetics,Safety,<5 kg body weight
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