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Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders.

Brasca Maria Gabriella,Gnocchi Paola,Nesi Marcella,Amboldi Nadia,Avanzi Nilla,Bertrand Jay,Bindi Simona,Canevari Giulia,Casero Daniele,Ciomei Marina,Colombo Nicoletta,Cribioli Sabrina,Fachin Gabriele,Felder Eduard R,Galvani Arturo,Isacchi Antonella,Motto Ilaria,Panzeri Achille,Donati Daniele

Bioorganic & Medicinal Chemistry（2015）

引用 13|浏览23
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摘要
Deconstruction of compound 1 led to the identification of the potent and orally bioavailable JAK2 inhibitor 16 (NMS-P830).
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关键词
JAK2,Myeloproliferative disorders,Protein kinase inhibitor,Tumour cell proliferation inhibition,Anti-cancer agents
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