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Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

Bin Zou,Wai Ling Chan,Mei Ding,Seh Yong Leong,Shahul Nilar,Peck Gee Seah,Wei Liu,Ratna Karuna,Francesca Blasco,Andy Yip,Alex Chao,Agatha Susila,Hongping Dong,Qing Yin Wang,Hao Ying Xu,Katherine Chan,Kah Fei Wan,Feng Gu,Thierry T. Diagana,Trixie Wagner,Ina Dix,Pei-Yong Shi,Paul W. Smith

ACS Medicinal Chemistry Letters（2015）

Cited 62|Views44
Key words
Dengue virus (DENV),spiropyrazolopyridones,structure-activity relationship,lead optimization
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