TET1 is a tumor suppressor of hematopoietic malignancy

Luisa Cimmino,Meelad M Dawlaty,Delphine Ndiaye-Lobry,Yoon Sing Yap,Sofia Bakogianni,Yiting Yu,Sanchari Bhattacharyya,Rita Shaknovich,Huimin Geng,Camille Lobry,Jasper Mullenders,Bryan King,Thomas Trimarchi,Beatriz Aranda-Orgilles,Cynthia Liu,Steven Shen, Amit K Verma,Rudolf Jaenisch,Iannis Aifantis

Nature Immunology（2015）

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摘要

Methylation of DNA CpG motifs is modulated in part by the TET family of epigenetic regulators. Aifantis and colleagues show that loss of TET1 function biases hematopoiesis toward the B cell lineage and promotes hematopoietic malignancies.

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