A fast capillary electrophoresis method to assess the binding affinity of recombinant antithrombin toward heparin directly from cell culture supernatants.

Anne-Lise Marie,Nguyet Thuy Tran,Elsa P Bianchini,François Saller,Stéphane Pautus,Toufik Abache,Jean-Luc Plantier,Rémi Urbain,Delphine Borgel,Myriam Taverna

Journal of Pharmaceutical and Biomedical Analysis（2015）

引用 7|浏览28

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摘要

•ACE method allowing the analysis of recombinant antithrombins directly from cell culture supernatants.•Binding constant measurement between recombinant antithrombin and heparin.•ACE method compatible with a low throughput screening.

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关键词

ACE,AT,BGE,CE,DE-ACE,EOF,FA,HEK,K,Kd,μep,NECEEM,PAGE,PVA,RSD,Serpin,SPR

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