Urinary Protein Selectivity In Nephrotic Syndrome And Pregnancy: Resurrection Of A Biomarker When Renal Biopsy Is Contraindicated
CLINICAL KIDNEY JOURNAL(2014)
Abstract
Significant proteinuria in pregnancy can indicate the presence of serious conditions requiring investigation and treatment. The nephrotic syndrome in pregnancy presents a multitude of difficulties and is a relative contraindication of renal biopsy, particularly in the third trimester. We present a case of nephrotic syndrome of unknown cause presenting at 33 weeks of pregnancy. With renal biopsy contraindicated, we used the urine protein selectivity test, a largely discarded test predicting steroid-responsive nephrotic syndrome, to help inform the decision to give steroids. This led to a successful clinical outcome including the avoidance of neonatal ICU care for baby.
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Key words
biomarker, nephrotic syndrome, pregnancy, protein selectivity, renal biopsy
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