Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Associated With Infectious Mononucleosis Due To Primary Epstein-Barr Virus Infection: Report Of Three Cases

CLINICAL KIDNEY JOURNAL(2014)

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Abstract
Although the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis remains unclear, it is generally believed that environmental factors such as infections contribute to its development of ANCA-associated vasculitis. Prior Epstein-Barr virus (EBV) infection is reported to be a trigger of systemic vasculitis. We herein report three cases of ANCA-associated vasculitis presenting with infectious mononucleosis due to primary EBV infection. The causal link between the two pathologies could not be proved, but primary EBV infection may play a role in the initiation or exacerbation of ANCA-associated vasculitis. Future studies are necessary to determine the interaction between these diseases conditions.
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Key words
anti-neutrophil cytoplasmic antibody, Epstein-Barr virus, infectious mononucleosis, vasculitis
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