BMS-871: A Novel Orally Active Pan-Notch Inhibitor As an Anticancer Agent
Bioorganic & Medicinal Chemistry Letters(2015)
摘要
This Letter describes synthesis, SAR, and biological activity of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides as inhibitors of γ-secretase mediated signaling of Notch receptors. Optimization of this series led to the identification of BMS-871 (compound 30) which displayed robust in vivo efficacy in Notch-dependent leukemia and solid tumor xenograft models.
更多查看译文
关键词
Anticancer,Notch inhibitor,T-acute lymphoblastic leukemia,Triple-negative breast cancer
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要