Effect of Huanshuai Recipe Oral Liquid (缓衰口服液) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis
Chinese Journal of Integrative Medicine(2015)
摘要
Objective To investigate the effect of Huanshuai Recipe Oral Liquid (缓衰口服液, HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS). Methods A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood urea nitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular fifiltration rate (eGFR) and CM syndrome score were compared between groups. Results After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were signifificantly decreased ( P <0.05 or P <0.01), and the eGFR in the treatment group were significantly increased ( P <0.05). Conclusion HSR can effectively improve the renal function and clinical symptoms of ARAS patients.
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关键词
atherosclerotic renal artery stenosis, Huanshuai Recipe Oral Liquid, renal dysfunction, Chinese medicine
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