Target Controlled Infusion for non-anaesthesiologist propofol sedation during gastrointestinal endoscopy: The first double blind randomized controlled trial.
Digestive and Liver Disease(2015)
摘要
Target Controlled Infusion is a sophisticated tool for providing optimal sedation regimen avoiding under or oversedation in gastrointestinal endoscopy.To compare standard moderate sedation vs. non-anaesthesiologist-administered propofol sedation during gastrointestinal endoscopy.Randomized controlled trial of 70 consecutive colonoscopies and 70 consecutive esophagogastroduodenoscopies (EGD). Standard group (n=70), received fentanyl (1μg/kg)+midazolam (0.03-0.04mg/kg) or midazolam only; propofol group (n=70), received fentanyl (1μg/kg)+propofol Target Controlled Infusion (1.2-1.6μg/ml) or propofol Target Controlled Infusion only. Discharge time, endoscopist satisfaction and patient satisfaction were recorded in all endoscopies.Colonoscopy: discharge time was significantly shorter in the propofol than the standard group (1.1±0.3 vs. 5±10.2min, respectively; P=0.03). Endoscopist satisfaction was significantly higher (98.3±11.4/100 vs. 87.2±12/100; P=0.001); patient satisfaction was significantly higher (95±9.3/100 vs. 85.5±14.4/100; P=0.002) in the propofol compared to the standard group. EGD: discharge time was not significantly different in the propofol and standard groups (1.1±0.7 vs. 3.9±9.2min, respectively; P=0.146). Endoscopist satisfaction was significantly higher (92.7±14.3/100 vs. 82.8±21.2/100; P=0.03); patient satisfaction was significantly higher (93.8±18.2/100 vs. 76.5±25.2/100; P=0.003). In the propofol group 94.3% of patients vs. 71.4% of patients in standard group asked to receive the same sedation in the future (P=0.021).Target Controlled Infusion is a promising method for non-anaesthesiologist-administered propofol sedation.
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关键词
Gastrointestinal endoscopy,Propofol,Sedation,Target Controlled Infusion
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