Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

Shanmugam Saravanan,Selvamurthi Gomathi,Bagavathi Kausalya,Jayaseelan Boobalan,Kailapuri G Murugavel,Pachamuthu Balakrishnan,Sarvode N Mothi,Sunil S Solomon, Nagalingeswaran Kumarasamy,Poongulali Selvamuthu,Suniti Solomon,Davey M Smith

AIDS RESEARCH AND HUMAN RETROVIRUSES（2015）

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摘要

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

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t-lymphocyte

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