In Vitro and In Vivo Antioxidant and Anti-inflammatory Activities of Abalone (Haliotis discus) Water Extract.

In this study, the in vitro and in vivo anti-inflammatory and antioxidant potentials of abalone (Haliotis discus) water extract were investigated. The taurine concentration of the abalone water extract was 593.80 nmol/mg, which was represented the most abundant total free amino acid. Abalone (Haliotis discus) water extract is a potent scavenger of free radicals, including DPPH, superoxide and alkyl radicals, which were investigated using a spin-trapping electron method and electron spin resonance (ESR) signal intensity. In addition, abalone (Haliotis discus) water extract showed a protective effect against 2,2′-azobis dihydrochloride (AAPH)-induced oxidative stress and cell death in the in vivo zebrafish model. Furthermore, we evaluated the anti-inflammatory effect of abalone water extract using the lipopolysaccharide (LPS)-stimulated zebrafish model. Abalone water extract markedly inhibited LPS-stimulated ROS and NO generation. In this study, it is proved that both the in vitro and in vivo anti-inflammatory as well as antioxidant potentials of abalone water extract, which contains taurine could be further utilized in relevant industrial applications.