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Abundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β.

Mizuki Yamamoto,Ryohei Yamamoto,Shigeo Takenaka,Satoshi Matsuyama,Kihei Kubo

Journal of Radiation Research（2015）

Cited 3|Views22
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Abstract
In mammalian cells, murine N-methylpurine DNA glycosylase (MPG) removes bases damaged spontaneously or by chemical agents through the process called base excision repair (BER). In this study, we investigated the influence of POL β deficiency on MPG-initiated BER efficiency and the expression levels of BER-related proteins in log-phase and growth-arrested (G 0 ) mouse embryonic fibroblasts (MEFs). ...
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Key words
BER,MPG,mouse,cell proliferation,POL β
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