Purity determination of amphotericin B, colistin sulfate and tobramycin sulfate in a hydrophilic suspension by HPLC.

Corina Pfeifer,Georg Fassauer,Hagen Gerecke,Thomas Jira,Yvonne Remane,Roberto Frontini,Jonathan Byrne,Robert Reinhardt

Journal of Chromatography B（2015）

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摘要

•Three HPLC methods were established for analyzing a complex mixed suspension.•Extraction procedures for three different active substances were developed.•A new HPLC method in combination with an ELSD was developed for the purity analysis of tobramycin.

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关键词

Amphotericin B,Colistin sulfate,Tobramycin sulfate,Suspension,HPLC,ELSD

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