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Matrix Metalloproteinase Inhibitor as an Antimicrobial Agent to Eradicate Enterococcus faecalis Biofilm.

Chiew Xsia Tay,Samantha Yiling Quah,Jeen Nee Lui,Victoria Soo Hoon Yu,Kai Soo Tan

Journal of Endodontics（2015）

Cited 25|Views2
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Abstract
•Phendione, a matrix metalloproteinase inhibitor, eradicated E. faecalis biofilm.•The antimicrobial effect of Phendione were unaffected by dentin debris.•The antimicrobial action of Phendione was primarily dependent on Zn2+.•Phendione also inhibited human MMP-2 activity.
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Key words
Biofilm,Enterococcus faecalis,matrix metalloproteinase inhibitor
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