Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation.

Nikoletta Szabó,Zoltán Iványi,Mihály Szécsi,János Julesz,Erzsébet Mernyák,Judit Huber,János Wölfling,Renáta Minorics,István Zupkó,Gyula Schneider

Steroids（2015）

引用 16|浏览3

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摘要

•Synthesis of 3-methoxycarbonyl-1-phenyl-5-pyrazolylandrostene derivatives.•Inhibition of the enzyme Δ5-3β-HSD by 17β-pyrazolylandrost-5-ene compounds.•Antiproliferative effects of 17β-pyrazolylandrost-5-ene compounds.

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关键词

Pregnenolone,Pregnadienolone,Methoxycarbonylpyrazolone,Antiandrogen effect,Antiproliferative action

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