Improved specificity of TALE-based genome editing using an expanded RVD repertoire

Jeffrey C Miller,Lei Zhang,Danny F Xia, John J Campo,Irina V Ankoudinova,Dmitry Y Guschin,Joshua E Babiarz,Xiangdong Meng,Sarah J Hinkley,Stephen C Lam,David E Paschon,Anna I Vincent, Gladys P Dulay,Kyle A Barlow,David A Shivak,Elo Leung, Jinwon D Kim,Rainier Amora,Fyodor D Urnov,Philip D Gregory,Edward J Rebar

NATURE METHODS（2015）

引用 76|浏览22

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摘要

This study extends the natural code by which transcription activation–like effector nucleases (TALENs) recognize DNA and uses the resulting expanded repertoire of repeat divariable residues (RVDs) to improve TALEN performance.

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Biotechnology, Genetic engineering

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