[192-POS]: Term and preterm preeclampsia: Are there two distinct phenotypes?

To determine differences in maternal and neonatal characteristics and outcomes in term and preterm pregnancies complicated by preeclampsia.Using a retrospective chart review design, we identified women with singleton gestations complicated by gestational hypertension, preeclampsia/eclampsia, or superimposed preeclampsia between January 2009 and December 2011. Maternal and neonatal characteristics and outcomes among term and preterm gestations were compared. Descriptive and comparison analyses were performed.Two hundred and thirty-eight women met the inclusion criteria. Of these, 87 were diagnosed and delivered at less than 37 weeks gestational age. Mean gestational age of preterm patients was 33.3±3.4 weeks. Women who delivered at a preterm gestation were more likely to have severe range blood pressures (79.5% vs. 59.3%, p<0.001), fetal growth restriction (20.7% vs. 3.3%, p<0.001), and oligohydramnios (10.3 % vs. 2.6%, p<0.001). Women in this group were more likely to have elevated liver function tests, LDH levels, proteinuria, and significantly lower platelet counts. They had higher cesarean delivery rates (78.3% vs. 55.3%, p<0.001) and lower rates of labor induction (58.0% vs. 78.9%, p=0.01). Neonates in the preterm group had significantly higher rates of NICU admission (57.5%), respiratory distress syndrome (47.1%), respiratory therapy for greater than 24h (26.4%), and assisted ventilation (13.8%); p<0.05. These neonates also had significantly lower 1 and 5-min APGAR scores and longer hospital stays; p<0.05.In the preterm period, preeclampsia appears to have greater adverse effects on the mother and neonate. These gestations have problems with impaired placental perfusion characterized by inadequate fetal growth and oligohydramnios, resulting in increased rates of neonatal morbidity and mortality. These data support the hypothesis that there may be distinct phenotypes of preeclampsia.A. Johnson: None. C. Federico: None. M. Martinez: None. K. Tran: None. E. Kao: None. N. Hooshvar: None. D. Tice: None. G. Wu: None. C. Gambala: None. G. Pridjian: None. C. Dola: None.