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Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

James Curtis,Yang Luo,Helen L Zenner,Delphine Cuchet-Lourenço,Changxin Wu,Kitty Lo,Mailis Maes,Ali Alisaac,Emma Stebbings,Jimmy Z Liu,Liliya Kopanitsa,Olga Ignatyeva,Yanina Balabanova,Vladyslav Nikolayevskyy,Ingelore Baessmann,Thorsten Thye,Christian G Meyer,Peter Nürnberg,Rolf D Horstmann,Francis Drobniewski,Vincent Plagnol,Jeffrey C Barrett,Sergey Nejentsev

NATURE GENETICS（2015）

Cited 134|Views23
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Abstract
Sergey Nejentsev and colleagues identify intronic variants in ASAP1 that associate with susceptibility to tuberculosis. They show that ASAP1 is downregulated in dendritic cells infected with Mycobacterium tuberculosis , impairing their migration and matrix degradation abilities.
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Key words
Genetic association study,Tuberculosis,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics
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