Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae.

Motoyasu Onishi,Mitsutaka Kitano,Keiichi Taniguchi,Tomoyuki Homma,Masanori Kobayashi,Tomokazu Yoshinaga,Akira Naito,Akihiko Sato

Antiviral Research（2015）

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摘要

•This study investigated the efficacy of peramivir against murine bacterial co-infection.•Peramivir inhibited viral replication, leading to bacterial clearance and prevention of mortality in bacterial co-infection.•The efficacy of peramivir was superior to that of oseltamivir against bacterial co-infection.

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关键词

Bacterial co-infection,Neuraminidase inhibitor,Peramivir,Influenza virus,Streptococcus pneumoniae

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