The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children.
Growth Hormone & IGF Research(2015)
摘要
•The impact of GHR genotype in prepubertal, idiopathic short children.•A tendency towards later transition from infancy to childhood growth in children homozygous for exon 3-deleted GHR.•Higher levels of IGFBP-3 in GHR exon 3-deleted homo- and heterozygotes.•No difference between GHR exon 3 genotypes in metabolic response to GH treatment.•No difference between GHR exon 3 genotypes in growth response to GH treatment.
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关键词
GHR,d3,DICT,ISS,GH,BMI,IGF-1,IGFBP-3,SDS,ICT,fl,ITT,PP,AH,ICP,AITT,SGA,GHmaxAITT,GHmax24h,GP-GRC,SWEDAC,DNA,PCR
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