No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants

Masakazu Hatano,Masashi Ikeda,Kenji Kondo,Takeo Saito,Ayu Shimasaki,Kosei Esaki,Wakako Umene-Nakano,Reiji Yoshimura,Jun Nakamura,Norio Ozaki,Nakao Iwata

Journal of Human Genetics（2015）

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Abstract

Antidepressants are the most commonly used treatment for patients with major depressive disorder (MDD). The remission rate, however, is insufficient; approximately one-third of patients taking these medications are considered to be ‘treatment resistant’. In addition, poor response or delay in finding an appropriate drug has a negative impact on the therapeutic effect.

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Key words

Genome-wide association studies,Human Genetics,Molecular Medicine,Gene Function,Gene Expression,Gene Therapy

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