How to mend a broken heart: adult and induced pluripotent stem cell therapy for heart repair and regeneration.

•Regeneration of cardiomyocyte in adult heart is possible.•Understand the heart diseases including genetic disorders by disease modelling.•New challenges of new targets on heart for regeneration and drug development.•Greatest therapeutic approaches by decellularisation and recellularisation.•In vivo cardiac reprogramming and cardiac differentiations.