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A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.

Friederike I Nollmann,Antje K Heinrich,Alexander O Brachmann,Christophe Morisseau,Krishnendu Mukherjee,Ángel M Casanova-Torres,Frederic Strobl,David Kleinhans,Sebastian Kinski,Katharina Schultz,Michael L Beeton,Marcel Kaiser,Ya-Yun Chu,Long Phan Ke,Aunchalee Thanwisai,Kenan A J Bozhüyük,Narisara Chantratita,Friedrich Götz,Nick R Waterfield,Andreas Vilcinskas,Ernst H K Stelzer,Heidi Goodrich-Blair,Bruce D Hammock,Helge B Bode

CHEMBIOCHEM（2015）

Cited 32|Views39
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Abstract
Simple urea compounds (phurealipids) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
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Key words
biosynthesis,entomopathogenic bacteria,juvenile hormone epoxide hydrolase inhibitor,natural products,Photorhabdus
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