Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2021.3

John P. Adelman,David E. Clapham,Hiroshi Hibino,Atsushi Inanobe,Lily Y. Jan,Andreas Karschin,Yoshihiro Kubo,Yoshihisa Kurachi,Michel Lazdunski,Takashi Miki,Colin G. Nichols,Lawrence G. Palmer,Wade L. Pearson,Henry Sackin,Susumu Seino,Paul A. Slesinger,Stephen Tucker,Carol A. Vandenberg

IUPHAR/BPS Guide to Pharmacology CITE（2021）

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Abstract

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

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Key words

potassium channels,gtopdb

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Inwardly rectifying potassium channels (K&lt;sub&gt;IR&lt;/sub&gt;) in GtoPdb v.2021.3

Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2021.3