Human T Cell Crosstalk Is Induced By Tumor Membrane Transfer
PLOS ONE(2015)
摘要
Trogocytosis is a contact-dependent unidirectional transfer of membrane fragments between immune effector cells and their targets, initially detected in T cells following interaction with professional antigen presenting cells (APC). Previously, we have demonstrated that trogocytosis also takes place between melanoma-specific cytotoxic T lymphocytes (CTLs) and their cognate tumors. In the present study, we took this finding a step further, focusing on the ability of melanoma membrane-imprinted CD8(+) T cells to act as APCs (CD8(+) T-APCs). We demonstrate that, following trogocytosis, CD8(+) T-APCs directly present a variety of melanoma derived peptides to fraternal T cells with the same TCR specificity or to T cells with different TCRs. The resulting T cell-T cell immune synapse leads to (1) Activation of effector CTLs, as determined by proliferation, cytokine secretion and degranulation; (2) Fratricide (killing) of CD8(+) T-APCs by the activated CTLs. Thus, trogocytosis enables cross-reactivity among CD8(+) T cells with interchanging roles of effectors and APCs. This dual function of tumor-reactive CTLs may hint at their ability to amplify or restrict reactivity against the tumor and participate in modulation of the anti-cancer immune response.
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关键词
Memory T Cells,T Cell Immunity
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