Angiotensin Ii Receptor Blocker Prevents Upper Gastrointestinal Bleeding In Hypertensive Patients With Chronic Kidney Disease Not On Dialysis

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE(2015)

引用 4|浏览1
暂无评分
摘要
AimsInvestigate if angiotensin II receptor blocker (ARB) decreases risk of upper gastrointestinal bleeding (UGIB) in hypertensive patients with chronic kidney disease (CKD) not on dialysis.MethodsAll hypertensive patients with CKD not on dialysis in outpatient department of China Medical University Hospital from 2003 to May 2013 were enrolled. The risk of UGIB was analysed using Cox proportional hazard regression.ResultsA total of 2744 hypertensive CKD patients including 1515 male and 1229 female, aged 64.913.8years old in a median of 1.9 (0.9-3.9) years were analysed. The incidence of UGIB was 4.5 per 100 patient-years. ARB was associated with a decreased risk of UGIB (p<0.001) with an adjusted hazard ratio (HR) of 0.533 [95% confidence interval (CI) 0.404-0.703]. A history of UGIB, Helicobacter pylori infection, diabetes, lower estimated glomerular filtration rate, elevated blood urea nitrogen and decreased serum albumin were independently associated with an increased risk of UGIB.ConclusionsAngiotensin II receptor blocker is associated with a decreased risk of UGIB in hypertensive CKD patients not on dialysis, independent of their renal function, history of gastrointestinal bleeding and nutrition status.
更多
查看译文
关键词
angiotensin,chronic kidney disease,hypertensive patients,upper gastrointestinal bleeding,gastrointestinal bleeding
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要