Disturbances to neurotransmitter levels and their metabolic enzyme activity in a freshwater planarian exposed to cadmium.
NeuroToxicology(2015)
Abstract
•We demonstrated the occurrence of 5-hydroxyindole-3-acetic acid in a planarian.•The substrate- and inhibitor-specificity of planarian MAO activity was observed.•Catechol-O-methyl transferase activity in the planarian was undetectable.•Altered dopamine and serotonin levels were observed in Cd-treated planarians.•Altered MAO-A and -B activities were also observed in Cd-treated planarians.
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Key words
AAADC,BA,CBN,Cd,COMT,CS,DA,DOPAC,FL,5-HIAA,HPLC–ECD,HRP,5-HT,HVA,LC50,l-DOPA,MAO,MAO-Is,3-MT,PEA,S-AMe,TA,TH,TPH
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