Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula
Nature Neuroscience(2015)
Abstract
This study shows that cocaine strengthens glutamatergic transmission, reduces K + channel function and drives hyperexcitability in lateral habenula neurons projecting to the rostromedial tegmental nucleus. The authors also show that GluA1 trafficking mediates these cellular modifications and is instrumental in a drug-mediated depressive-like phenotype.
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Key words
Addiction,Cellular neuroscience,Neurotransmitters,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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