Anti-thyroid and antifungal activities, BSA interaction and acid phosphatase inhibition of methimazole copper(II) complexes

Chemico-Biological Interactions(2015)

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摘要
•Cu–Met–phen denotes strong inhibition effect on phosphatase acid (AcP) activity.•Cu–Met–phen presents anti-thyroid activity being 106 times more active than Met.•Albumin interaction experiments indicate high affinity toward the complexes.•Calculated binding constants indicate reversible binding to the protein.
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关键词
Methimazole,Phenanthroline,Copper(II),Antifungal activity,Anti-thyroid activity,BSA interactions
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