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[Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia].

Jitai Zhang,Kele Wu,Xinyun Xu,Ziwei Liu,Chong Lin,Yuhuan Wang,Hongtao Yan, Xinyun Yang

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics（2015）

Cited 3|Views8
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Abstract
No linear correlation was found between placental IGF-1 expression and methylation level of IGF-1 promoter with a hypomethylation status. The contribution of placental IGF-1 expression to birth weight is bidirectional. Increased expression seems to promote fetal growth, while decreased expressions may curb overgrowth, therefore control fetal growth in a relatively normal range.
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Key words
Macrosomia,Placenta,IGF-1 gene,DNA methylation
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