TGF-β1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes.
Cancer Letters(2015)
Abstract
•MiR-155 is positively related to the levels of liver cancer stem cell markers CD90, CD133 and Oct4 in enriched spheres.•MiR-155 regulates the migration and invasion of liver cancer cells.•MiR-155 regulates liver cancer cell EMT and acquisition of CSCs via direct targeting of TP53INP1.•TGF-β1 indirectly regulates TP53INP1 expression via miR-155 in liver cancer cells.•Overexpression of TGF-β1 in spheres and extracellular TGF-β1 induces intracellular TGF-β1 expression.
MoreTranslated text
Key words
Epithelial–mesenchymal transition,Cancer stem cell,MiR-155,Tumour sphere,TP53INP1
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined