Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

TGF-β1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes.

Fengchao Liu,Xin Kong,Lin Lv,Jian Gao

Cancer Letters（2015）

Cited 85|Views4
No score
Abstract
•MiR-155 is positively related to the levels of liver cancer stem cell markers CD90, CD133 and Oct4 in enriched spheres.•MiR-155 regulates the migration and invasion of liver cancer cells.•MiR-155 regulates liver cancer cell EMT and acquisition of CSCs via direct targeting of TP53INP1.•TGF-β1 indirectly regulates TP53INP1 expression via miR-155 in liver cancer cells.•Overexpression of TGF-β1 in spheres and extracellular TGF-β1 induces intracellular TGF-β1 expression.
More
Translated text
Key words
Epithelial–mesenchymal transition,Cancer stem cell,MiR-155,Tumour sphere,TP53INP1
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined