Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.
Cell Calcium(2015)
摘要
•External acidosis affects P2Y receptor dependent Ca2+ signalling in microglia.•External acidosis strongly reduced P2Y receptor dependent Ca2+ influx.•There was little impact of external acidosis on P2Y receptor dependent Ca2+ release.•Extracellular acidosis inhibited P2Y receptor induced but not basal migration.
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关键词
P2Y receptors,Microglia,Acidosis,Store-operated Ca2+ entry,Migration
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