The allele T of rs10852936 confers risk for early-onset psoriasis

•The associations of rs10852936 with the phenotypic traits of psoriasis are studied in a large Chinese Han population.•The susceptibility effect of the risk allele T of rs10852936 declines with increasing age at psoriasis onset.•The allele T of rs10852936 confers risk for early-onset psoriasis.•Single nucleotide polymorphisms in the region surrounding the IKZF3-ZPBP2 locus influence psoriasis phenotype.