The neuropathology of stillbirth - correlation with apolipoprotein genotype in a Scottish population based study.

Early Human Development(2015)

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摘要
•The paper compares neuropathology findings with APOE genotype in a population cohort of 191 stillbirths.•Multiple pregnancy stillbirths show the most brain damage, followed by antepartum, abruption, then intrapartum stillbirths.•In most cases the neuropathological findings appeared relatively recent, particularly in intrapartum deaths.•β-Amyloid precursor protein positive axons (36% stillbirths overall) correlate closely with white matter injury (p<0.0001).•APOE2 was significantly overrepresented in stillbirths but APOE genotype did not correlate with neuropathological findings.
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关键词
Stillbirth,Neuropathology,Brain injury,β-Amyloid precursor protein,β-Amyloid,Apolipoprotein E
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