糖尿病肾病肾组织氧化应激的调控机制及中药的干预作用
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica（2014）
Abstract
在糖尿病肾病(diabetic nephropathy,DN)发生、发展过程中机体内活性氧簇(reactive oxygen species,ROS)生成增多导致肾组织OS损伤的发生;其形态学特征主要表现为肾小球和肾小管固有细胞结构和功能的改变.肾组织OS调控途径涉及胞内多条信号通路,其中,p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路和腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)信号通路作为多种抗氧化物质的靶点而发挥着重要功能.中药复方或单味中药提取物对DN肾组织OS损伤的干预作用包括“调控ROS和抗氧化物质,减少晚期糖基化终末产物形成,抑制生长因子表达,影响胞内信号通路活性”等.
MoreTranslated text
Key words
diabetic nephropathy,Chinese herbal medicine,oxidative stress,signaling pathway,pharmacological mechanism
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined