Ring closure activates yeast γTuRC for species-specific microtubule nucleation

Justin M Kollman,Charles H Greenberg,Sam Li,Michelle Moritz,Alex Zelter,Kimberly K Fong,Jose-Jesus Fernandez,Andrej Sali,John Kilmartin,Trisha N Davis,David A Agard

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2015）

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摘要

The γ-tubulin ring complex (γTuRC) nucleates microtubules in the cell. The functional, closed state of yeast γTuRC is now visualized, and its microtubule-nucleating activity is found to be species specific.

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nature structural and molecular biology, science

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